The Response of the Injured Articular Cartilage of Rabbit Knee after Injection of Autologous Blood.
- Author:
Soo A KIM
1
;
Eui Han KIM
;
Jin Il KIM
;
Il JANG
;
Ji Soo LEE
;
Yang Kyun LEE
Author Information
1. Department of Rehabilitation Medicine and 1Pathology, Soonchunhyang University College of Medicine. sooapmr@hanmail.net
- Publication Type:Original Article
- Keywords:
Articular cartilage;
Proliferant;
Dextrose;
Blood
- MeSH:
Animals;
Cartilage;
Cartilage, Articular*;
Glucose;
Knee*;
Patella;
Rabbits
- From:Journal of the Korean Academy of Rehabilitation Medicine
2005;29(4):406-412
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To evaluate the effects of proliferant by injecting blood into the articular cartilage defect. METHOD: The patella of rabbits were dislocated laterally and 2 mm circular and 2 mm depth full-thickness defect was made in the articular cartilage. We injected 0.2 cc autologous blood to the right defect and normal saline to the left one at 1 week after operation for six times with a 1 week interval. After injection for six weeks, the articular cartilage defect were obtained and stained with H-E and S-100. RESULTS: The surface of the saline-injected group was easily distinguishable from the surrounding articular cartilage. But the blood-injected group had similar appearance to the surrounding cartilage, with the margin of the defect barely discerptible. Strong S-100 stained immune cartilage cells were observed in the blood-injected group. CONCLUSION: The repairing process of the injured articular cartilage using autologous blood was shown to be much better than that of saline-injected group although the observation period was short and the number of animal was small. So we found that autologous blood effectively repaired osteochondral defects.
