Severe Chronic Active Epstein-Barr Virus Infection Presenting as Fever of Unknown Origin.
- Author:
Kyeongman JEON
1
;
Eung Ho KIM
;
Jun Seong SON
;
Hyun Ha CHANG
;
Sook In JUNG
;
Won Sup OH
;
Kyong Ran PECK
;
Jae Hoon SONG
;
Kwang Cheol KOH
;
Chul Won JUNG
;
Young Hyeh KOH
Author Information
1. Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea. krpeck@smc.samsung.co.kr
- Publication Type:Case Report
- Keywords:
Epstein-Barr virus;
Fever of unknown origin;
Severe chronic active Epstein-Barr virus infection
- MeSH:
Burkitt Lymphoma;
Diagnosis;
Epstein-Barr Virus Infections;
Fever of Unknown Origin*;
Fever*;
Genome;
Herpesvirus 4, Human*;
Humans;
Infectious Mononucleosis;
Lymphoproliferative Disorders
- From:
Infection and Chemotherapy
2003;35(4):215-220
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Epstein-Barr virus (EBV) is one of eight human herpesvirus. Primary infection with EBV in childhood is generally asymptomatic or mild, however, often causes overt diseases such as infectious mononucleosis (IM) and lymphoproliferative disorder (LPD), the latter occursing in immunologically compromised individuals. Historically, EBV has been considered to be etiologically linked to human malignancies such as EBV genome positive Burkitt's lymphoma and nasopharyngeal carcinoma. Recently, however, another category of EBV-related disease, "chronic active EBV infection", has been made to describe persons without a clearly defined underlying disease. We report 4 cases of patients, presented with episodic fever of unknown origin (FUO), who were diagnosed as severe chronic active EBV infection. A combined application of serology for EBV and in-situ hybridization established the diagnosis of the EBV infection.
