A Case of Disseminated Cryptococcosis in an Immunocompetent Adult.
- Author:
Sun Hee PARK
1
;
Su Mi CHOI
;
Yang Ree KIM
;
Dong Gun LEE
;
Sang Il KIM
;
Seong Heon WIE
;
Myung Seok KIM
;
Ji Han JUNG
;
Jung Hyun CHOI
;
Jin Hong YOU
;
Kyo Young LEE
;
Wan Shik SHIN
;
Moon Won KANG
Author Information
1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. infect@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Cryptococcosis;
Disseminated;
Immunocompetent
- MeSH:
Adult*;
Amphotericin B;
Biopsy;
Cryptococcosis*;
Fever;
Fluconazole;
Flucytosine;
Granuloma;
HIV;
Humans;
Immunocompromised Host;
Lymph Nodes;
Lymphatic Diseases;
Meningitis;
Recurrence;
Skin
- From:
Infection and Chemotherapy
2004;36(4):245-250
- CountryRepublic of Korea
- Language:English
-
Abstract:
Disseminated cryptococcosis is a systemic infection that occurs most commonly in immunocompromised patients, especially those with human immunodeficiency virus (HIV) infection. Although the attack rate is much higher among immunocompromised patients, cryptococcal disease does occur in persons without any apparent predisposing conditions. A previously healthy 26-year- old man was admitted to the hospital because of persistent fever and cervical lymphadenopathy. Despite empirical antibiotic therapy, he developed cutaneous erythematous papules, generalized lymphadenopathy, miliary pulmonary infiltration, and meningitis successively soon after admission. Biopsy of the skin and the cervical lymph node revealed chronic granuloma with cryptococcal organisms and tissue culture of lymph node confirmed cryptococcal infection. He was treated with intravenous amphotericin B plus flucytosine for 2 weeks, and then with fluconazole for 2 months. After the therapy, there was no evidence of recurrence for 2 years.
