A Case of Mycobacterium avium Pulmonary Disease with Massive Pleural Effusion in an HIV-negative, Nonimmunosuppressed Patient: Using PCR-Restriction Fragment Length Polymorphism Assay.
- Author:
Sang Soo KIM
1
;
Eun Jae RHIE
;
Geun Jun KO
;
Hyung Seob CHOI
;
Hwa Eun OH
;
June Myung KIM
;
Kkot Sil LEE
Author Information
1. Department of Internal, College of Medicine, Kwandong University, Koyang, Korea. florid@kwandong.ac.kr
- Publication Type:Case Report
- Keywords:
Mycobacterium-avium complex;
Pleural effusion;
Restriction Fragment Length Polymorphism Assay
- MeSH:
Adult;
Asymptomatic Infections;
Chest Pain;
Clarithromycin;
Ethambutol;
Exudates and Transudates;
Fever;
Humans;
Lung;
Lung Diseases*;
Mycobacterium avium Complex;
Mycobacterium avium*;
Mycobacterium*;
Pleural Diseases;
Pleural Effusion*;
Pleurisy;
Rifampin;
Streptomycin;
Thorax
- From:
Infection and Chemotherapy
2004;36(6):381-385
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The Mycobacterium avium complex (MAC) comprises slow-growing mycobacteria that is ubiquitous in the environment and capable of infecting diverse species with consequences ranging from asymptomatic infection to clinically significant and even fatal disease. Especially, basal pleural disease is infrequently found in immunocompetent person. We report a very rare case of M. avium pleuritis with massive pleural effusion without any predisposing conditions. A previously healthy 36-year-old man was admitted to our hospital because of generalized malaise, low-grade fever, and right pleuritic chest pain of 5 days' duration. Chest X-ray showed mottled infiltration in the right upper lung zone with minimal right pleural effusion which was exudate with lymphocyte-dominance. The pleural effusion progressively increased without responding to anti-tuberculosis treatment. Afterwards M. avium was identified from the pleural effusion using PCR-Restriction Fragment Length Polymorphism Assay(PCR-RFLP). The treatment regimen was changed to rifampine, ethambutol, clarithromycin and streptomycin afterwhich the patient recovered.
