Catheter-Related Trichosporon asahii Bloodstream Infection in a Neutropenic Patient with Myelodysplastic Syndrome.
- Author:
Se Eun GO
1
;
Kyung Jin LEE
;
Yaeni KIM
;
Jae Ki CHOI
;
Yoo Jin KIM
;
Dong Gun LEE
Author Information
- Publication Type:Case Report
- Keywords: Trichosporon asahii; Catheter-related infection; Fungemia; Voriconazole; Stem cell transplantation
- MeSH: Anti-Bacterial Agents; Antifungal Agents; Arm; Catheter-Related Infections; Ciprofloxacin; Fungemia; Humans; Immunocompromised Host; Incidence; Itraconazole; Leg; Mortality; Myelodysplastic Syndromes*; Prognosis; Skin; Stem Cell Transplantation; Trichosporon*; Voriconazole
- From:Infection and Chemotherapy 2018;50(2):138-143
- CountryRepublic of Korea
- Language:English
- Abstract: Because primary antifungal prophylaxis is widely used for immunocompromised hosts, the incidences of unusual fungal infections have increased. Trichosporon asahii has emerged as an important life-threatening opportunistic systemic pathogen because of the increased use of cytotoxic or immunosuppressant agents, along with high mortality rates. Here, we describe a case of catheter-related T. asahii bloodstream infection with multiple septic skin nodules in both the arms and legs of the patient who was in the neutropenic period after allogeneic stem cell transplantation for myelodysplastic syndrome treated with prophylactic ciprofloxacin and itraconazole. We successfully treated her with intravenous voriconazole for more than a month without any complications. Clinicians should consider breakthrough Trichosporon infections when clinical progress in an immunocompromised patient with unexplained infection signs and symptoms does not improve despite proper treatment with antibiotics or various antifungal agents. In addition, voriconazole can be a good treatment choice for achieving better treatment results and prognosis.
