Usage Analysis of Surgical Prophylaxis of Cephalosporins and Aminoglycosides in a University Hospital.
- Author:
Insoo RHEEM
1
;
Hyunjoo PAI
;
Eun Kyoung CHOI
;
Hyung Tae OH
;
Dae Ok CHOI
;
Woo Sung PARK
Author Information
1. Department of Laboratory Medicine, Dankook University College of Medicine, Cheonan, Korea. insoo@dankook.ac.kr
- Publication Type:Original Article
- Keywords:
Prophylaxis;
Surgery;
Cephalosporin;
Aminoglycoside
- MeSH:
Aminoglycosides*;
Anti-Bacterial Agents;
Appendectomy;
Cephalosporins*;
Dichlorodiphenyldichloroethane;
Humans;
Retrospective Studies;
Surgical Procedures, Operative
- From:
Infection and Chemotherapy
2004;36(1):24-31
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: According to previous investigation on antibiotic use at Dankook University Hospital, cephalosporin and aminoglycoside were the most commonly used antibiotics accounting for 52.8% and 30.4% of total antibiotics used, respectively. In almost all cases, antibiotics were prescribed for prophylaxis rather than for treatment the ratio for prophylaxis vs. treatment intent was 3.9:1 and 3.6: 1 for cephalosporin and aminoglycoside, respectively. Thus, we performed a study to investigate the current usage of cephalosporin and aminoglycoside before and after the surgical procedures. METHODS: We retrospectively analyzed the appropriateness of prophylactic use of antibiotics on 14 major operative procedures (26.4% of total operations) for patients discharged during July, 1997. RESULTS: Among 8 kinds of operative procedure performed on 105 cases, in which prophylactic antibiotic use was recommended, appropriate antibiotic use was observed in only 2 cases of non- perforating appendectomy. For 7 operative procedures, in which use of 1st generation cephalosporin is recommended, 1st cephalosporins were used only on 37.8% (44/92) of cases, whereas 2nd cephalosporins were used for most of other cases. An average of 2.5 DDD of 2nd cephalosporin, which was a pertinent dose, was used on non-perforating appendectomy. However, on all the other 7 operative procedures, the dose exceeded the recommended dose. Inappropriate antibiotic use was observed for 6 operative procedures, for which prophylactic antibiotic use was not recommended. The combination of cephalosporin and aminoglycoside was used in all but 3 types of operative procedures. CONCLUSION: During most of the pre- and post-operative period, antibiotics were combined, overused, misused, and inappropriately used.
