Susceptibility of Clinical Isolates of Acinetobacter baumannii and Pseudomonas aeruginosa to Colistin and Polymyxin B in Korea.
- Author:
Wonkeun SONG
1
;
Tae Jae LEE
;
Min Jeong PARK
;
Han Sung KIM
;
Jae Seok KIM
;
Heung Jeong WOO
;
Kyu Man LEE
Author Information
1. Department of Laboratory Medicine, Hallym University College of Medicine, Korea. swonkeun@hallym.or.kr
- Publication Type:Original Article
- Keywords:
Acinetobacter baumannii;
Pseudomonas aeruginosa;
Colistin;
Polymyxin B
- MeSH:
Acinetobacter baumannii*;
Acinetobacter*;
Aminoglycosides;
beta-Lactams;
Ceftazidime;
Ciprofloxacin;
Colistin*;
Hospitals, University;
Imipenem;
Korea*;
Polymyxin B*;
Polymyxins*;
Pseudomonas aeruginosa*;
Pseudomonas*
- From:
Infection and Chemotherapy
2006;38(6):362-366
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The emergence of multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa has become a major problem. The use of nontraditional agents such as colistin and polymyxin B have been tried. The purpose of this study was to evaluate the colistin and polymyxin B susceptibility of A. baumannii and P. aeruginosa isolates in Korea. MATERIALS AND METHODS: According to susceptibility of ceftazidime and imipenem, selected 93 isolates of A. baumannii and 99 isolates of P. aeruginosa were collected from 5 university hospitals in Korea. Susceptibility to colistin and polymyxin B was tested using the reference broth microdilution method. RESULTS: The rates of other beta-lactams, aminoglycosides, and ciprofloxacin susceptibility were high (58-100%, 50-100%, and 75-100%, respectively) in ceftazidime- and imipenem-susceptible isolates but were low (< or =31%, < or =47%, and < or =18%, respectively) in ceftazidime- or imipenem-resistant isolates (P<0.05). Colistin and polymyxin B displayed a nearly identical spectrum of activity, exhibiting excellent potency against A. baumannii (MIC50/90, 1/2 microgram/mL) and P. aeruginosa (MIC50/90, 1/1 microgram/mL). Only one of the A. baumannii isolates was resistant to colistin (MIC, 4 microgram/mL), but the isolate was susceptible to polymyxin B (MIC, 2 microgram/mL). CONCLUSION: In Korea, no A. baumannii and P. aeruginosa isolates were resistant to both colistin and polymyxin B. These data suggested that polymyxins may be alternative drugs for multidrug-resistant A. baumannii and P. aeruginosa isolates.
