Eradication Rate of Lansoprazole-Based Triple Therapy in Peptic Ulcer Patients with Helicobacter pylori and Efficacy of Urea Breath Test in Evaluating Helicobater pylori Eradication.
- Author:
Hye Kyung JUNG
1
;
Kwac Jae JIN
;
Min Ah YOU
;
Ki Sun BAE
;
Jung Mi KWON
;
Jong Soo LEE
;
Doe Young KIM
;
Il Hwan MOON
Author Information
1. Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea. kimdy@mm.ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Helicobacter pylori;
Eradication;
Lansoprazole;
Urea breath test
- MeSH:
Amoxicillin;
Breath Tests*;
Clarithromycin;
Endoscopy;
Helicobacter pylori*;
Helicobacter*;
Humans;
Korea;
Lansoprazole;
Peptic Ulcer*;
Prospective Studies;
Ulcer;
Urea*;
Urease
- From:
Infection and Chemotherapy
2003;35(3):154-159
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: There are only a few studies on Helicobacter pylori (H. pylori) for its eradication rates of lansoprazole-based triple therapy in Korea, and the results are controversial. Therefore, we undertook to investigate the eradication rate of lansoprazole-based triple therapy, and compare the concordance rate of urea breath test (UBT) and rapid urease test (RUT) in evaluating H. pylori eradication. METHODS: Patients with acute peptic ulcer who were H. pylori-positive were recruited by prospective, consecutive manner. They received lansoprazole 30 mg b.d., amoxicillin 1 g b.d. and clarithromycin 500 mg b.d. for 1 week. Upper endoscopy was performed after 4 weeks to check for ulcer healing, and UBT and RUT were performed to evaluate H. pylori eradication status. RESULTS: A total of 46 patients were recruited, and they were all compliant. H. pylori eradication rate was 87.0% (40/46) and ulcer healing rate was 91.3% (42/46). Forty one patients showed negative in both UBT and RUT, and 4 patients revealed positive in both tests, therefore, the concordance rate of UBT and RUT was 97.8% (45/46). CONCLUSION: Our study showed that 1-week lansoprazole-based triple therapy was effective in H. pylori eradication and ulcer healing. UBT can be an effective, noninvasive method for evaluating H. pylori status after H. pylori eradication.
