A Case of Good's Syndrome.
- Author:
Kyoung Ho SONG
1
;
Kye Hyung KIM
;
Chung Jong KIM
;
Kyoung Un PARK
;
Sanghoon JHEON
;
Hong Bin KIM
;
Nam Joong KIM
;
Myoung Don OH
;
Kang Won CHOE
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Korea. hbkimmd@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Good syndrome;
Thymoma;
Immunodeficiency;
Hypogammaglobulinemia
- MeSH:
Adult;
Agammaglobulinemia;
B-Lymphocytes;
Cough;
Humans;
Immunity, Cellular;
Immunoglobulins;
Lymphopenia;
Male;
Sinusitis;
T-Lymphocytes;
Thymoma
- From:
Infection and Chemotherapy
2007;39(5):259-262
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Good's syndrome is the association of thymoma with immunodeficiency, characterized by hypogammaglobulinemia, B-cell lymphopenia and variably defects in cellular immunity with CD4+ T-cell lymphopenia and an inverted CD4+:CD8+ T-cell ratio. We report a 43-year-old male patient who presented with a 18-month history of productive cough and postnasal drip. One year ago, he underwent the operation for resection of a thymoma. Despite of appropriate management, sinusitis relapsed multiple times. He was found to have hypogammaglobulinemia with nearly absent B cells(4/microliter). The CD4+ T-cell count was 554/microliter with an inverted CD4+:CD8+ T-cell ratio of 0.6. His symptoms and signs improved with antibiotic treatment and monthly administration of intravenous immunoglobulin (IVIG, 400 mg/kg).
