The External Ventricular Drain-related Ventriculitis: Organisms and Appropriateness of Empiric Antibiotic Therapy.
- Author:
Byung Hun DO
1
;
Shin Woo KIM
;
Jong Taek OH
;
Jong Won SON
;
Sang Woo HA
;
Eung Kap LEE
;
Hyun Ha CHANG
;
Jong Myung LEE
;
Nung Soo KIM
Author Information
1. Department of Internal Medicine, Kyungpook National University College of Medicine, Daegu, Korea. ksw2kms@mail.knu.ac.kr
- Publication Type:Original Article
- Keywords:
Central nervous system infections;
Meningitis;
Neurosurgical Procedures
- MeSH:
Acinetobacter;
Acinetobacter Infections;
Catheters;
Ceftazidime;
Ceftriaxone;
Central Nervous System Infections;
Coagulase;
Coinfection;
Enterococcus;
Fever;
Gyeongsangbuk-do;
Humans;
Meningitis;
Methicillin Resistance;
Methicillin-Resistant Staphylococcus aureus;
Mortality;
Muscle Rigidity;
Neurosurgical Procedures;
Retrospective Studies;
Staphylococcus;
Streptococcus pneumoniae;
Vancomycin
- From:
Infection and Chemotherapy
2005;37(2):92-98
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate the etiologic microorganisms of external ventricular drain (EVD)-related ventriculitis and the appropriateness of using ceftazidime and vancomycin as an empiric therapy in neurosurgical patients with EVD-related ventriculitis. MATERIALS AND METHODS: Retrospective analysis of 39 patients with EVD-related ventriculitis among 340 neurosurgical patients to whom EVD had been placed during December 2000 and October 2003 at Kyungpook National University Hospital. RESULTS: Thirty-nine EVD-related infections (39/340, 11.5%) occurred and the attributable mortality rate was 10.3% (4/39). The average duration from the ventricular catheter placement to the development of ventriculitis was 8.4 days. All patients with EVD infection had fever and 89.7% (35/39) of the patients showed nuchal rigidity. The positive culture rate in CSF was 87.1% (34/39) and the frequency of individual organism is as follows:Acinetobacter 45% (19 cases), methicillin-resistant coagulase negative Staphylococcus 22% (9 cases), methicillin-resistant Staphylococcus aureus 22% (9 cases), Enterococcus 5% (2 cases), Streptococcus pneumoniae 3% (1 case), non-fermenting gram-negative bacilli 3% (1 case). The polymicrobial infection rate was 15.4% (6/39). Among 19 cases of Acinetobacter infection, 42.1% (8/19) of the strains showed resistance to ceftriaxone and 15.7% (3/11) to ceftazidime. However, all cases were sensitive to meropenem. CONCLUSION: These findings show that the major etiologic organisms causing EVD-related ventriculitis have recently changed to Gram-negative non-fermenters, especially Acinetobacter. Because Gram-negative non-fermenting rods resistant to ceftazidime are increasing, an immediate change from ceftazidime plus vancomycin, the widely accepted empiric antibiotic therapy, to meropenem plus vancomycin should be considered when clinical symptoms and signs show no improvement or even deterioration.
