Tuberculous Lymphadenitis in Patients with Myelogenous Leukemia.
- Author:
Chang Seop LEE
1
;
Jin Su SONG
;
Pyoeng Gyun CHOE
;
Jae Hyun CHO
;
Ji Whan BANG
;
Kyung Hwa PARK
;
Wan Beom PARK
;
Hong Bin KIM
;
Nam Joong KIM
;
Sung Soo YOON
;
Seonyang PARK
;
Byoung Kook KIM
;
Myoung Don OH
;
Kang Won CHOE
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. mdohmd@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Mycobacterium tuberculosis;
Acute myelogenous leukemia;
Lymphadenopathy
- MeSH:
Adult;
Diagnosis;
Diagnosis, Differential;
Drug Therapy;
Humans;
Induction Chemotherapy;
Leukemia;
Leukemia, Biphenotypic, Acute;
Leukemia, Lymphoid;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive;
Leukemia, Myeloid*;
Leukemia, Myeloid, Acute;
Lymph Nodes;
Lymphatic Diseases;
Mycobacterium tuberculosis;
Tuberculosis;
Tuberculosis, Lymph Node*
- From:
Infection and Chemotherapy
2006;38(5):266-270
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
During the neutropenic phase, leukemia patients receiving chemotherapy are prone to bacterial and, fungal infections; occasionally mycobacterial, viral and protozoal organisms may also cause infections. Mycobacterium tuberculosis infection was reported very rarely in these patients. This report describes four patients with M. tuberculosis infection identified from 185 adult patients who were diagnosed myelogenous leukemia between January 2003, and December 2004. There was no patient with M. tuberculosis infection from 44 lymphoid leukemia and 11 acute biphenotypic leukemia patients. Sites of infection were all lymph nodes. Three among four patients were presented with lymphadenopathy at initial diagnosis of leukemia, and the other one presented with lymphadenopathy after induction chemotherapy. There was no patient presented with lymphadenopathy during the neutropenic phase. Tuberculous lymphadenitis was presented in a patient with three acute myelogenous leukemia (FAB class 2 M4, 1 M2) and a chronic myelogenous leukemia, accelerated phase. An acute myelogenous leukemia patient had a leukemic cell and tubercle bacilli in the same lymph node. Tuberculosis should also be included as a differential diagnosis in myelogenous leukemia patient with lymphadenopathy, especially in the countries in which the disease is endemic.
