Chemoprophylaxis and Serological Follow-Up in Brucella abortus Exposed Laboratory Workers.
- Author:
Chang Seop LEE
1
;
Hye Soo LEE
;
Jae Hyeon LEE
;
Jin Hee PARK
;
Young Sil CHOI
;
Kyu Jam HWANG
;
Heung Bum LEE
Author Information
- Publication Type:Original Article
- Keywords: Laboratory workers; Brucella spp.; Chemoprophylaxis
- MeSH: Aerosols; Agar; Anti-Bacterial Agents; Brucella; Brucella abortus; Chemoprevention; Compliance; Doxycycline; Follow-Up Studies; Rifampin; Serologic Tests; Sprains and Strains
- From: Infection and Chemotherapy 2008;40(2):107-109
- CountryRepublic of Korea
- Language:Korean
- Abstract: The aerozolization is one of possible Brucella transmission mechanisms, particularly in air-borne exposed laboratory workers. In this study, seven laboratory workers were potentially exposed to B. abortus via aerosols. Two laboratory workers who sniffed an agar plate several times were considered to be at high risk for acquiring the disease, 5 workers who did not work directly with the strain were be considered at low risk of infection. Prophylactic antibiotics of doxycycline 200 mg/day and rifampin 600 mg/day were offered for 6 weeks in high risk workers and 3 weeks for low risk workers, respectively. Enrolled workers were advised to check for serological testing of Brucella species every 3 weeks during a total period of 12 weeks. Compliance with taking medicine was 57.1% (4/7) and compliance for completing the serological tests was 85.7% (6/7). None of the laboratory workers developed clinical disease or tested positive serologically during 3 months of serological testing and 1 year of clinical follow-up.
