In vitro Antimicrobial Activity of Cefcapene against Clinical Isolates.
- Author:
Eun Ju CHOO
1
;
Yee Gyung KWAK
;
Mi Suk LEE
;
Jin Yong JEONG
;
Sang Ho CHOI
;
Nam Joong KIM
;
Yang Soo KIM
;
Jun Hee WOO
;
Jiso RYU
Author Information
1. Division of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. yskim@amc.seoul.kr
- Publication Type:In Vitro ; Original Article
- Keywords:
Cefcapene;
Cephalosporin;
Minimal inhibitory concentrations
- MeSH:
Agar;
Cephalosporins;
Chungcheongnam-do;
Gram-Negative Bacteria;
Gram-Positive Bacteria;
Haemophilus influenzae;
Humans;
Moraxella (Branhamella) catarrhalis;
Respiratory System;
Respiratory Tract Infections;
Staphylococcus aureus;
Streptococcus;
Streptococcus pneumoniae;
Tertiary Care Centers
- From:
Infection and Chemotherapy
2005;37(3):133-137
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Cefcapene pivoxil hydrochloride is a new oral cephem which has a broad-spectrum activity with expanded potency against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus, as well as Gram-negative bacteria. In this study, we examined the in vitro activity of cefcapene against recently isolated clinical specimens from patients in a tertiary hospital. MATERIALS AND METHODS: We tested the in vitro antimicrobial activities of cefcapene and other cephalosporins against 450 clinical isolates from of patients in Asan Medical Center. Minimal inhibitory concentrations (MICs) were determined by agar dilution method according to the recommendations of National Committee for Clinical Laboratory Standards. RESULTS: Compared with other cephalosporins (cefaclor, cefpodoxime, and cefixime), cefcapene had lower MIC distributions for Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and methicillin-susceptible S. aureus. Cefcapene had variable activity against Enterobateriaceae. CONCLUSION: Cefcapene had excellent in vitro antimicrobial activities against common typical bacterial respiratory tract pathogens and methicillin-susceptible S. aureus. Cefcapene appears to be a promising agent for treatment of community-acquired respiratory tract infections and infections caused by methicillin-susceptible S. aureus.
