Two Cases of Candida inconspicua Infection in Neutropenic Patients with Acute Leukemia.
- Author:
Hyun Young WOO
1
;
Sun Hee PARK
;
Dong Gun LEE
;
Hyun Sun JO
;
Chang Ki MIN
;
Myungshin KIM
;
Kyungja HAN
;
Wan Shik SHIN
Author Information
1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. fire@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Candida inconspicua;
Fungemia;
Neutropenia
- MeSH:
Amphotericin B;
Antifungal Agents;
Candida*;
Candidemia;
Danazol;
Deoxycholic Acid;
Fluconazole;
Fungemia;
Gastrointestinal Tract;
Hematologic Neoplasms;
Humans;
Immunocompromised Host;
Itraconazole;
Korea;
Leukemia*;
Neutropenia
- From:
Infection and Chemotherapy
2006;38(3):164-168
- CountryRepublic of Korea
- Language:English
-
Abstract:
Non-albicans Candida species which are resistant to azole are emerging as important pathogens in patients with hematological malignancies who received antifungal prophylaxis. C. inconspicua is one of rare Candida spp. and resistant to fluconazole and deep infection due to C. inconspicua has not been reported in Korea so far. We reported here two cases of candidemia due to C. inconspicua in neutropenic patients with acute leukemia. C. inconspicua were presumed to be originated from gastrointestinal tract in both cases. The antifungal susceptibility test of C. inconspicua in case 1 showed resistance to fluconazole and itraconazole. Both cases were successfully treated by amphotericin B deoxycholate. Clinicians should keep in mind that non-albicans Candida species would be emerging pathogen in immunocompromised hosts and early recognition and appropriate use of antifungal agents is necessary.
