Two Cases of Aspergillus Endocarditis in Patients with Acute Lymphoblastic Leukemia.
- Author:
Sung Chul SHIN
1
;
Kyong Ran PECK
;
Jung Jae HONG
;
Bong Geun SONG
;
Dong Hee KIM
;
Kyeongman JEON
;
Je Wook CHAE
;
Jun Seong SON
;
Sook In JUNG
;
Won Sup OH
;
Jae Hoon SONG
Author Information
1. Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. krpeck@smc.samsung.co.kr
- Publication Type:Case Report
- Keywords:
Aspergillosis;
Leukemia;
Endocarditis;
Osteomyelitis
- MeSH:
Amphotericin B;
Aspergillosis;
Aspergillus*;
Central Nervous System;
Cerebral Hemorrhage;
Drug Therapy;
Early Diagnosis;
Endocarditis*;
Fever;
Hematologic Neoplasms;
Humans;
Induction Chemotherapy;
Invasive Pulmonary Aspergillosis;
Leukemia;
Mortality;
Osteomyelitis;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*;
Recurrence;
Sepsis;
Stem Cell Transplantation;
Stem Cells;
Transplantation;
Young Adult
- From:
Infection and Chemotherapy
2003;35(5):332-336
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Although Aspergillus endocarditis has rarely been reported, it can cause fatal complications in hematologic malignancy patients and allogeneic stem cell transplant recipients. We experienced two cases of aspergillus endocarditis developed in acute lymphoblastic leukemia patients. Case; A 19-year-old patient developed Aspergillus endocarditis after allogenic hemopoietic stem cell transplantation. He was treated with surgical intervention and liposomal amphotericin B. He died of recurred Aspergillus endocarditis and cerebral hemorrhage probably related with aspergillosis of central nervous system. Case 2; A 23-year-old patient developed invasive Aspergillus endocarditis after induction chemotherapy. Aspergillus endocarditis was successfully treated by surgical intervention and amphotericin B. He died of refractory neutropenic fever and sepsis after the third relapse of leukemia and repetitive chemotherapy. He probably had invasive pulmonary aspergillosis without evidence of endocarditis recurrence. Because the mortality of Aspergillus endocarditis is very high, early diagnosis and surgical intervention are very important for better outcome.
