Factors Associated with Insulin Resistance in a Middle-Aged Non-Obese Rural Population: The Chungju Metabolic Disease Cohort (CMC) Study.
- Author:
Sun Young LIM
1
;
Hee Sung HA
;
Hyuk Sang KWON
;
Jin Hee LEE
;
Hyeon Woo YIM
;
Kun Ho YOON
;
Won Chul LEE
;
Ho Young SON
;
Yong Moon PARK
Author Information
1. Graduate School of Public Health, The Catholic University of Korea, Seoul, Korea. markYMpark@gmail.com
- Publication Type:Original Article
- Keywords:
Abdominal obesity;
BMI;
Insulin resistance
- MeSH:
Adult;
Aged;
Body Mass Index;
Cohort Studies;
Female;
Homeostasis;
Humans;
Insulin;
Insulin Resistance;
Life Style;
Male;
Metabolic Diseases;
Obesity, Abdominal;
Prevalence;
Rural Population;
Social Class;
Waist Circumference
- From:Epidemiology and Health
2011;33(1):e2011009-
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: We aimed to determine the characteristics affecting insulin resistance in non-obese middle-aged adults in a rural community. METHODS: A total of 1,270 non-diabetic adults aged between 40 and 64 years old with body mass index (BMI) less than 25 kg/m2 were analyzed. Subjects with insulin resistance were defined as those who had the highest quartile value of the homeostasis model assessment of insulin resistance (HOMA-IR) in a non-diabetic population. RESULTS: A total of 217 subjects (20.6%) had insulin resistance. Prevalence of metabolic syndrome was significantly higher in insulin-resistant subjects in both men (29.3% vs. 10.3%) and women (34.1% vs. 15.6%). Among metabolic syndrome components, elevated waist circumference and elevated triglyceride were higher in insulin-resistant subjects in both genders. After being controlled for socioeconomic status and lifestyle related covariates, the association between insulin resistance and BMI was statistically significant in the category of 23.0-24.9 kg/m2 in men (adjusted OR, 4.63; 95% confidence interval [95% CI], 1.77-12.15) using the category of 18.5-20.9 kg/m2 as a reference. In addition, the association between insulin resistance and abdominal obesity was statistically significant only for men (adjusted OR, 2.57; 95% CI, 1.29-5.11). CONCLUSION: Insulin resistance appears to be highly associated with high BMI and abdominal obesity, even in non-obese, non-diabetic middle-aged men.
