Adiponectin is Associated with Impaired Fasting Glucose in the Non-Diabetic Population.
- Author:
Sang Yeun KIM
1
;
Sun Ju LEE
;
Hyoun Kyoung PARK
;
Ji Eun YUN
;
Myoungsook LEE
;
Jidong SUNG
;
Sun Ha JEE
Author Information
1. Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea. jsunha@yuhs.ac
- Publication Type:Original Article
- Keywords:
Adiponectin;
Diabetes;
Impaired fasting glucose;
Insulin resistance
- MeSH:
Adiponectin;
Fasting;
Female;
Glucose;
Homeostasis;
Humans;
Insulin Resistance;
Logistic Models;
Male;
Odds Ratio;
Waist Circumference
- From:Epidemiology and Health
2011;33(1):e2011007-
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: Adiponectin is strongly associated with diabetes in the Western population. However, whether adiponectin is independently associated with impaired fasting glucose (IFG) in the non-obese population is unknown. METHODS: The serum adiponectin, insulin resistance (IR), and waist circumference (WC) of 27,549 healthy Koreans were measured. Individuals were then classified into tertile groups by gender. IFG was defined as a fasting serum glucose of 100-125 mg/dL without diabetes. IR was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR). The association of adiponectin and IFG was determined using logistic regression analysis. RESULTS: WC and adiponectin were associated with IFG in both men and women. However, the association of WC with IFG was attenuated in both men and women after adjustment for the HOMA-IR. Adiponectin was still associated with IFG after adjustment for and stratification by HOMA-IR in men and women. Strong combined associations of IR and adiponectin with IFG were observed in men and women. Multivariate adjusted odds ratios (ORs) (95% confidence interval [CI]) among those in the highest tertile of IR and the lowest tertile of adiponectin were 9.8 (7.96 to 12.07) for men and 24.1 (13.86 to 41.94) for women. CONCLUSION: These results suggest that adiponectin is strongly associated with IFG, and point to adiponectin as an additional diagnostic biomarker of IFG in the non-diabetic population.
