Human papillomavirus infection and risk of lung cancer in never-smokers and women: an 'adaptive' meta-analysis.
- Author:
Jong Myon BAE
1
;
Eun Hee KIM
Author Information
- Publication Type:Meta-Analysis ; Review
- Keywords: Lung neoplasms; Risk factor; Human papillomavirus; Meta-analysis
- MeSH: Case-Control Studies; Female; Humans*; Incidence; Lung Neoplasms*; Lung*; Male; Odds Ratio; Papillomavirus Infections*; Risk Factors
- From:Epidemiology and Health 2015;37(1):e2015052-
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVES: The incidence of lung cancer in Koreans is increasing in women and in both men and women with a never-smoking history. Human papillomavirus (HPV) infection has been suggested as a modifiable risk factor of lung cancer in never-smokers and women (LCNSW). This systematic review (SR) aimed to evaluate an association between HPV infection and lung cancer risk in LCNSW. METHODS: Based on a prior SR and some expert reviews, we identified refereed, cited, or related articles using the PubMed and Scopus databases. All case-control studies that reported the odds ratio of HPV infection in LCNSW were selected. An estimate of the summary odds ratio (SOR) with 95% confidence intervals (CI) was calculated. RESULTS: A total of four case-control studies were included. The fixed-effect model was applied because of homogeneity (I-squared=0.0%). The SORs in women and in never-smokers were 5.32 (95% CI, 1.75 to 16.17) and 4.78 (2.25 to 10.15) respectively. CONCLUSIONS: These results showed a significant effect of HPV infection in LCNSW. It is evident that developing a preventive plan against LCNSW may be necessary.
