Human papillomavirus 16 infection as a potential risk factor for prostate cancer: an adaptive meta-analysis.
- Author:
Jong Myon BAE
1
Author Information
- Publication Type:Meta-Analysis ; Review
- Keywords: Prostate neoplasms; Human papillomavirus 16; Risk factor; Meta-analysis; Oncogenic viruses
- MeSH: Asian Continental Ancestry Group; Carcinogenesis; DNA; Hand; Human papillomavirus 16*; Humans; Incidence; Korea; Odds Ratio; Oncogenic Viruses; Passive Cutaneous Anaphylaxis; Prevalence; Prostate; Prostatic Neoplasms*; Risk Factors*
- From:Epidemiology and Health 2015;37(1):e2015005-
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVES: Although an expert review published in 2013 concluded that an association between human papillomavirus (HPV) infection and prostate cancer (PCa) risk had not yet been firmly established, a 2011 systematic review of 14 articles revealed an increased prevalence of HPV-16 DNA in PCa tissues. Another meta-analysis of the related articles is needed to evaluate the potential link between HPV infection and PCa risk. METHODS: A snowballing search strategy was applied to the previously cited articles in the above-mentioned expert review and systematic review. Additional articles selected for this meta-analysis should fulfill all following inclusion criteria: (a) evaluation of detected HPV-16 DNA in tissue samples and the PCa risk and (b) report of the HPV-16 prevalence in both cancer and control tissues. Estimated summary odds ratios (sOR) with 95% confidence intervals (CI) were calculated using fixed effect or random-effect models. RESULTS: Hand searching identified 16 new articles. The sOR of the total 30 articles indicated a significant HPV-16 infection-related increase in the PCa risk (sOR, 1.851; 95% CI, 1.353 to 2.532, I2=37.82%). CONCLUSIONS: These facts provide additional supportive evidence for a causal role of HPV-16 infection in prostate carcinogenesis. As the PCa incidence rates have increased rapidly in Asian countries, including Korea, during the last several decades, further studies of HPV-related PCa carcinogenesis may be necessary.
