Generalized Primary Amyloid Lymphadenopathy.
10.5045/kjh.2009.44.4.320
- Author:
Jin Hyun PARK
1
;
Ji Hyun KWON
;
Ji Won KIM
;
Hyeon Jin CHO
;
Ki Hwan KIM
;
Doo Hyun CHUNG
;
Inho KIM
;
Sung Soo YOON
;
Seonyang PARK
;
Byoung Kook KIM
Author Information
1. Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. ssysmc@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Systemic amyloidosis;
Multiple lymph node enlargement;
Chemotherapy
- MeSH:
Amyloid;
Amyloidosis;
Biopsy;
Birefringence;
Breast Neoplasms;
Dexamethasone;
Eosinophils;
Female;
Humans;
Lymph Nodes;
Lymphatic Diseases;
Mastectomy, Radical;
Melphalan;
Middle Aged;
Polymers
- From:Korean Journal of Hematology
2009;44(4):320-324
- CountryRepublic of Korea
- Language:English
-
Abstract:
Systemic amyloidosis is a disease that displays deposition of insoluble polymeric protein fibrils in tissues and organs. We report here on a case of a 64-year-old woman who initially presented with multiple enlarged lymph nodes. Computed tomography showed multiple enlarged lymph nodes in the mediastinal, lower cervical, supraclavicular, axillary and abdominal areas. Excision biopsy of the cervical lymph nodes and the subsequent histopathology showed amorphous eosinophilic material deposits, and these revealed apple-green birefringence on a polarizing microscopic examination on the Congo-red stained slide. The patient was diagnosed with amyloidosis and she received chemotherapy consisting of melphalan and dexamethasone. During chemotherapy, she was diagnosed with breast cancer. After modified unilateral radical mastectomy, the dexamethasone was restarted and this therapy resulted in stable disease.
