Synchronous development of KIT positive acute myeloid leukemia in a patient with gastrointestinal stromal tumor.
- Author:
Young Bin JOO
1
;
Seung Hwa CHOI
;
Seung Kyoung KIM
;
Byungyong SHIM
;
Myung Shin KIM
;
Yoo Jin KIM
Author Information
- Publication Type:Case Report
- Keywords: KIT; Acute myeloid leukemia; Gastrointestinal stromal tumor
- MeSH: Benzamides; Biopsy; Bone Marrow; Dizziness; Female; Gastrointestinal Stromal Tumors; Humans; Induction Chemotherapy; Karyotype; Karyotyping; Leukemia, Myeloid, Acute; Middle Aged; Neoplasm Metastasis; Pancytopenia; Piperazines; Point Mutation; Pyrimidines; Shock, Septic; Imatinib Mesylate
- From:Korean Journal of Hematology 2010;45(1):66-69
- CountryRepublic of Korea
- Language:English
- Abstract: We report a case of synchronous occurrence of KIT-positive acute myeloid leukemia (AML) and gastrointestinal stromal tumor (GIST). A 63-year-old woman was hospitalized for dizziness, and abdominal computed tomography revealed an exophytic gastric mass and hepatic metastasis. The patient was diagnosed with GIST and was administered imatinib (400 mg/day) for the metastatic unresectable tumor. After 2 weeks of imatinib treatment, the patient developed pancytopenia, which persisted even after the drug was discontinued, thereby necessitating bone marrow biopsy. Biopsy examination indicated AML, and karyotyping revealed a complex karyotype. We did not observe point mutations at residues D816 and N822 of KIT. Therefore, the patient received standard induction chemotherapy, but on the 18th day after completion of chemotherapy, she died of septic shock and multi-organ failure. Since KIT plays an important role in both GIST and AML, we consider that both these malignancies may have been associated with each other.
