Intracranial Relapse of Intravascular Large B-Cell Lymphoma After Completion of CHOP Chemotherapy.
- Author:
Tae Min KIM
1
;
Jin Soo KIM
;
Tae Yong KIM
;
Jong Mu SUN
;
Sae Won HAN
;
Yong Sang HONG
;
Dong Wan KIM
;
Seock Ah IM
;
Tae You KIM
;
Sung Soo YOON
;
Dae Seog HEO
;
Yung Jue BANG
;
Seonyang PARK
;
Byoung Kook KIM
;
Noe Kyeong KIM
Author Information
1. Department of Internal Medicine, Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. heo1013@plaza.snu.ac.kr
- Publication Type:Case Report
- Keywords:
Intravascular large B-cell lymphoma;
CHOP chemotherapy;
Intracranial relapse
- MeSH:
Aged;
B-Lymphocytes*;
Biopsy;
Bone Marrow;
Brain;
Breast;
Doxorubicin;
Drug Therapy*;
Female;
Fever;
Humans;
Lymphoma;
Lymphoma, B-Cell*;
Recurrence*;
Skin;
Vincristine
- From:Korean Journal of Hematology
2004;39(3):177-181
- CountryRepublic of Korea
- Language:English
-
Abstract:
Intravascular large B-cell lymphoma (IVLBL) is a rare neoplasm characterized by proliferation of lymphoma cells within the lumina of small vessels. Neurological and skin involvements usually predominate. We would describe a 78-year-old woman presented with fever, multiple erythematous skin lesions, and language disturbance. The skin biopsy of breast revealed IVLBL and malignant cells were also seen in the bone marrow. Shortly after completion of six cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) with clinical response, intracranial relapse with multiple brain masses occurred. The palliative whole brain radiation therapy was given and intensive chemotherapy should be investigated in the case presented here.
