Influential Factors for Engraftment in Autologous Peripheral Hematopoietic Stem Cell Transplantation (APBSCT).
10.5045/kjh.2007.42.4.301
- Author:
Ki Ju JEUNG
1
;
Myung Soo KANG
;
Ki Du KWON
;
Kyoung Ha KIM
;
Jong Chan LEE
;
Sang Chul LEE
;
Hyun Jung KIM
;
Sang Byung BAE
;
Chan Kyu KIM
;
Nam Su LEE
;
Kyu Taeg LEE
;
Sung Kyu PARK
;
Jong Ho WON
;
Dae Sik HONG
;
Hee Sook PARK
Author Information
1. Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea.
- Publication Type:Original Article
- Keywords:
Engraftment;
Autologous;
Stem cell transplantation
- MeSH:
Blood Platelets;
Cell Count;
Cytarabine;
Diagnosis;
Etoposide;
Hematologic Neoplasms;
Hematopoietic Stem Cell Transplantation*;
Hematopoietic Stem Cells*;
Hemorrhage;
Humans;
Leukemia, Myeloid, Acute;
Metabolic Diseases;
Mortality;
Multiple Myeloma;
Multivariate Analysis;
Neutropenia;
Neutrophils;
Research Personnel;
Retrospective Studies;
Stem Cell Transplantation;
Thrombocytopenia
- From:Korean Journal of Hematology
2007;42(4):301-308
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Autologous peripheral hematopoietic stem cell transplantation (APBSCT) has been widely used to treat various types of hematological disorders, metabolic diseases and congenital immunodeficiency. Hematopoietic recovery is important because prolonged duration of neutropenia and thrombocytopenia is associated with a higher risk of infection, bleeding and treatment related mortality. Many investigators have studied the factors that affect hematopoietic recovery after stem cell transplantation. METHODS: We retrospectively investigated the factors influencing hematopoietic engraftment in 112 patients with hematological malignancies and solid tumors who received APBSCT. We evaluated the gender, age, CD34+ cell number, conditioning regimens, and the type of tumor and their association with neutrophil and platelet engraftment. RESULTS: Post-transplant neutrophil engraftment (>500/microL) required a median of 11 days (range 6~50) and platelet engraftment 12 (range 1~78) days (>20,000/microL). The univariate analysis showed that the factors that positively affected hematopoietic recovery were: the type of conditioning regimens such as BEAM (BCNU, etoposide, cytosine arabinoside, melphalan) and BEAC (BCNU, etoposide, cytosine arabinoside, cyclophosphamide) versus BC (busulfan, cyclophosphamide), the CD34+ cell number and the disease diagnosis such as multiple myeloma versus acute myelogenous leukemia. The multivariate analysis showed only the CD34+ cell number (5~10 x 10(6)/kg) to be significantly associated with early neutrophil and platelet engraftment (P<.001). CONCLUSION: These findings suggest that measurement of the CD34+ cell count may be sufficient to predict the time to engraftment after APBSCT.
