A t(3;3)(q21;q26) Acute Myeloid Leukemia with the Philadelphia Chromosome as a Secondary Change.
- Author:
Jin Yeong HAN
1
;
Kyeong Hee KIM
;
Jae Seok KIM
;
Hyo Jin KIM
;
Ryung NAM
Author Information
1. Department of Clinical Pathology, Dong-A University, College of Medicine.
- Publication Type:Original Article
- Keywords:
Philadelphia chromosome;
Secondary event;
Acute myeloid leukemia;
t(3;
3)
- MeSH:
Clonal Evolution;
Cytogenetics;
Disease Progression;
Female;
Humans;
Hydrogen-Ion Concentration;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive;
Leukemia, Myeloid, Acute*;
Middle Aged;
Philadelphia Chromosome*
- From:Korean Journal of Hematology
2000;35(1):67-71
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The Philadelphia chromosome (Ph) appears as a secondary change at the onset of disease. However, a late-appearing or secondary Ph has also been observed in rare cases of chronic myeloid leukemia and even more unusual events of acute myeloid leukemia. We recently experienced a 63-year-old female patient with the M1 subtype of acute myeloid leukemia. Cytogenetic studies revealed t(3;3)(q21;q26) as the primary change and the Ph translocation as the additional (secondary) anomaly. These findings further support the conclusion that the Ph plays a role not only in multistep leukemogenesis but also in clonal evolution related to disease progression.
