A Case of Primary Pleural Effusion Lymphoma.
- Author:
Seung Hyun JUNG
1
;
Dae Young ZANG
Author Information
1. Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea. fhdzang@kornet.net
- Publication Type:Case Report
- Keywords:
Primary effusion lymphoma;
Human herpesvirus-8;
Human immunodeficiency virus
- MeSH:
B-Lymphocytes;
Biopsy;
Chest Pain;
Exudates and Transudates;
Fatigue;
Genotype;
Herpesvirus 8, Human;
HIV;
Humans;
Lymphatic Diseases;
Lymphoma*;
Lymphoma, Primary Effusion;
Middle Aged;
Pleura;
Pleural Effusion*;
Polymerase Chain Reaction;
Radiography;
Thorax;
Tomography, X-Ray Computed
- From:Korean Journal of Hematology
2002;37(4):297-301
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Primary effusion lymphoma (PEL) is a recently described subtype of malignant lymphoma which develops in association with human herpesvirus-8 (HHV-8) in human immunodeficiency virus (HIV)-infected patients. PEL presents predominantly as lymphomatous effusion in the body cavities without a definite mass or lymphadenopathy. The malignant cell has large-cell morphology with null immunophenotype and B-cell genotype. We describe an unusual case of HIV negative HHV-8 negative PEL patient. A 48-year-old man presented with symptoms of right lower chest pain and fatigue for 3 months. Chest radiography and CT scan showed right pleural effusion and pleural thickening and no evidence of lymphadenopathy. Examination of the pleural fluid revealed lympho-dominant exudate and the results of all cultures were negative. A malignant lymphoma of diffuse large B-cell type was confirmed by pleural biopsy. The results of serologic studies for HIV and PCR of HHV- 8 using pleura fluid and tissue were all negative.
