A Case of Leukemic Transformation in Essential Thrombocythemia Treated with Hydroxyurea.
- Author:
Ji Hyun LEE
1
;
Tae Ik KIM
;
Geun Tae KIM
;
Yong Hwan LEE
;
Sun Dong JEONG
;
Mi Hwa JANG
;
Ho Kyun KIM
;
Byung Chang KIM
Author Information
1. Department of Internal Medicine, Maryknoll Hospital, Pusan, Korea.
- Publication Type:Case Report
- Keywords:
Leukemic transformation;
Essential thrombocythemia;
Hydroxyurea
- MeSH:
Bone Marrow;
Hemorrhage;
Hydroxyurea*;
Hyperplasia;
Leukemia;
Mortality;
Myeloproliferative Disorders;
Prognosis;
Thrombocythemia, Essential*;
Thrombocytosis
- From:Korean Journal of Hematology
1997;32(3):433-439
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Essential thrombocythemia is a myeloproliferative disorder, characterized by marked thrombocytosis and marrow megakaryocytic hyperplasia. Although the major causes of morbidity and mortality are bleeding and thromboembolic events, the long-term prognosis is favorable and leukemic transformation is rare. We report a case of acute leukemia following treatment of Philadelphia chromosome-negative essential thrombocythemia with hydroxyurea for 4 years with a brief review of literature.
