A Case of Unusual Clinical Course in Patient with Hemorrhagic Fever with Renal Syndrome Associated with Secondary Amyloidosis.
- Author:
Jeong Eun LEE
1
;
Young Rok DO
;
Sang Il KIM
;
Won Sig LEE
;
Hong Suk SONG
Author Information
1. Department of Internal Medicine, Keimyung University, School of Medicine, Taegu, Korea.
- Publication Type:Case Report
- Keywords:
Hemorrhagic fever with renal syndrome;
Amyloidosis
- MeSH:
Acute Kidney Injury;
Amyloid;
Amyloidosis*;
Biopsy;
Birefringence;
Bone Marrow;
Fever;
Hantaan virus;
Hemorrhagic Disorders;
Hemorrhagic Fever with Renal Syndrome*;
Histiocytes;
Humans;
Immunohistochemistry;
Lymphocytosis;
Myalgia;
Potassium Permanganate;
Thrombocytopenia
- From:Korean Journal of Hematology
1997;32(3):440-445
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hemorrhagic fever with renal syndrome (HFRS) is a symptom complex of fever, chill, myalgia, hemorrhagic diathesis and acute renal failure. We experienced a case of non-oliguric HFRS associated severe thrombocytopenia. Peripheral blood smear showed large atypical lymphocytosis and hemophagocytic histiocytes on bone marrow aspiration. Hantaan virus antibody titer was 1:5,120. Congo-red stain after potassium permanganate treatment of bone marrow biopsy revealed yellow-green birefringence and immunohistochemistry for AA amyloid antibody showed weak positive staining in the stroma of the bone marrow. Herein, we report a case of unusual HFRS associated with secondary amyloidosis and review the literature.
