A Case of AML Atypical M2 with Granulocytic Sarcoma in the Meninges Induced Remission by All-Trans Retinoic Acid and Combined Chemotherapy.
- Author:
Jea Sung SEO
1
;
Moo Rim PARK
;
Kyeoung Sang CHOI
;
Oh Won TAE
;
Je Jung LEE
;
Ik Joo CHUNG
;
Hyeoung Joon KIM
;
Duk CHO
;
Dong Wook YANG
Author Information
1. Department of Internal Medicine, Chonnam University Medical School, Kwangju, Korea.
- Publication Type:Case Report
- Keywords:
AML atypical M2;
Granulocytic sarcoma;
All-trans retinoic acid (ATRA)
- MeSH:
Cytarabine;
Daunorubicin;
Drug Therapy*;
Granulocytes;
Humans;
Leukemia, Promyelocytic, Acute;
Meninges*;
Sarcoma;
Sarcoma, Myeloid*;
Tretinoin*
- From:Korean Journal of Hematology
1997;32(3):453-458
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We repoarted a rare case of AML atypical M2 who developed granulocytic granulocyte sarcoma in the meninges which was induced complete remission with all-trans retinoic acid (ATRA), daunorubicin and cytosine arabinoside (Ara-C). Morphological and immunophenotypic study of leukemic cells in this patient suggested acute promyelocytic leukemia. However, leukemic clees lacked both t (15;17) and PML-RARalpha gene rearragement, rather showed t (8;21). The patient was diagnosed as AML atypical M2.
