A Case of Splenic Lymphoma with Villous Lymphocytes.
- Author:
Myung Shin KIM
1
;
Ah Won LEE
;
Yonggoo KIM
;
Kyungja HAN
;
Chang Suck KANG
;
Sang In SHIM
;
Sungkyu PARK
;
Chun Choo KIM
;
Eung Guk KIM
Author Information
1. Department of Clinical Pathology, Catholic University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Splenic lymphoma;
Villous lymphocytes;
B cell;
Immunophenotype
- MeSH:
Aged;
B-Lymphocytes;
Basophils;
Bone Marrow;
Cytogenetics;
Cytoplasm;
Humans;
Leukocyte Count;
Lymphatic Diseases;
Lymphocytes*;
Lymphocytosis;
Lymphoma*;
Lymphoproliferative Disorders;
Male;
Spleen;
Splenomegaly
- From:Korean Journal of Hematology
1997;32(3):459-464
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Splenic lymphoma with villlous lymphocytes (SLVL) is a B cell chronic lymphoproliferative disorder which affects predominantly elderly males. Most patients present with splenomegaly without lymphadenopathy and a lymphocytosis. This report describes a case of SLVL in 66 year old male who complained abdominal discomfort and abdominal mass. The leukocyte count was 47.8x109/L with 89% atypical lymphocytes showing variable amout of moderately basophilic cytoplasm and unevenly distributed or polar cytoplasmic villi. The bone marrow was effaced with these neoplastic lymphocytes. The immunophenotype of the neoplastic B cells was CD19 (+), CD20 (+), CD22 (+), CD11c (+), CD2 (-), CD3 (-), CD5 (-), CD10 (-), CD25 (-) and CD15 (-). The cytogenetic findings exhibited 46,XY,del (3) (q24),del (10) (p12). The spleen was weighted 520g and had nodular infiltrates of neoplastic B cells in the region of the white pulp with minimal red pulp involvement.
