A Case of Coexistence with Myelodysplastic Syndrome and Paroxysmal Nocturnal Hemoglobinuria: Confirmed by Reticulocytes Survival Test and Glycosylphosphatidylinositol (GPI)-linked Protein Test.
- Author:
Ji Hyang LIM
1
;
Yonggoo KIM
;
Dong Wook KIM
;
Jong Yul JIN
;
Chi Wha HAN
;
Kyungja HAN
;
Sang In SHIM
;
Chun Choo KIM
Author Information
1. Department of Clinical Pathology, College of Medicine, Catholic University, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
MDS;
PNH;
Reticulocytosis;
Reticulocyte survival test;
GPI-linked protein
- MeSH:
Biopsy;
Bone Marrow;
Clone Cells;
Erythrocytes;
Erythroid Cells;
Follow-Up Studies;
Glycosylphosphatidylinositols*;
Hemoglobinuria;
Hemoglobinuria, Paroxysmal*;
Humans;
Hyperplasia;
Myelodysplastic Syndromes*;
Neutrophils;
Reticulocytes*;
Reticulocytosis
- From:Korean Journal of Hematology
1997;32(3):465-469
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A patient presenting paroxysmal nocturnal hemoglobinuria (PNH) cloned cells in the course of myelodysplastic syndrome (MDS) with reticulocytosis is described. The bone marrow biopsy demonstrated erythroid hyperplasia and moderate dysplasia. Mild hemoglobinuria was detected but the Ham test was negative. The reticulocyte survival test revealed sustained survival curve indicating delayed reticulocyte maturation regarded as the characteristic of MDS cloned erythroid cells. The glycosylphosphatidylinositol-linked protein deficient neutrophils and erythrocytes population regarded as PNH clones were identified by flow cytometric analysis using monoclonal antibody. From these results, we concluded that MDS and PNH cloned cells were coexisited in this patient. In this patient, long-term follow-up observation could clarify whether MDS and PNH were arising from the same clone or from two distinct clones.
