Report of Two Patients with Severe Aplastic Anemia Who Showed Trilineage Hematologic Response to Low-dose Erythropoietin.
- Author:
Kwang Woon SEO
1
;
Wee Soo CHAE
;
Suk Bong JEON
;
Woo Jin SUNG
;
Man Gi PARK
;
Jong Gwang KIM
;
Sang Kyun SOHN
;
Kyu Bo LEE
Author Information
1. Department of Internal Medicine, Kyungpook National University, School of Medicine, Daegu, Korea. sksohn@knu.ac.kr
- Publication Type:Case Report
- Keywords:
Aplastic anemia;
Erythropoietin;
Trilineage response
- MeSH:
Anemia, Aplastic*;
Antilymphocyte Serum;
Bone Marrow;
Bone Marrow Transplantation;
Cyclosporine;
Erythropoietin*;
Humans;
Pancytopenia
- From:Korean Journal of Hematology
2002;37(4):282-286
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Aplastic anemia is characterized by multilineage bone marrow failure resulting in pancytopenia. There is no effective therapy for patients with severe aplastic anemia who were refractory to immunosuppresive therapy including antithymocyte globulin (ATG) or relapsed after allogeneic bone marrow transplantation. We report hereby that two patients with severe aplastic anemia who were relapsed after immu-nosuppresive therapy with ATG and cyclosporine A were successfully treated with low dose erythropoietin. Observed trilineage hematologic response was dependent on low dose erythropoietin therapy.