A Case Report of Posttransplant Lymphoproliferative Disorders Successfully Treated with R-CHOP in Korea.
10.5045/kjh.2008.43.2.106
- Author:
Sul Hee YOON
1
;
Soo Jeong KIM
;
Hye Won LEE
;
Doh Yu HWANG
;
Jin Seok KIM
;
June Won CHEONG
;
Yoo Hong MIN
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. minbrmmd@yumc.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Posttransplant;
Lymphoproliferative;
R-CHOP
- MeSH:
Antibodies, Monoclonal, Murine-Derived;
Antiviral Agents;
B-Lymphocytes;
Cyclophosphamide;
Doxorubicin;
Herpesvirus 4, Human;
Immunosuppression;
Kidney Transplantation;
Korea;
Lymphoproliferative Disorders;
Prednisolone;
Stem Cell Transplantation;
Vincristine;
Rituximab
- From:Korean Journal of Hematology
2008;43(2):106-112
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Posttransplant lymphoproliferative disorder (PTLD) is a group of heterogeneous lymphoid diseases that cause serious complications after organ or stem cell transplantation. The onset of PTLD is mostly due to EBV infection-induced B-cell proliferation and a defect in cytotoxic T cell function that occurs with immunosuppression. The usual treatment strategy for PTLD is reduction or withdrawal of immunosuppressive drugs with or without the administration of antiviral agents. Recently, various studies on the efficacy of rituximab or chemotherapy have been reported. We report two cases of rapidly progressing and complicated PTLDs after kidney transplantation that were successfully treated with a combination regimen consisting of rituximab, cyclophosphamide, adriamycin, vincristine and prednisolone (R-CHOP).
