A Case of Henoch-Schonlein Purpura Associated with Diffuse Large B Cell Lymphoma.
10.5045/kjh.2007.42.2.162
- Author:
Il Du KIM
1
;
Seung Geun LEE
;
Hye Jeong LEE
;
Woo Sung JO
;
Young Jin CHOI
;
Ho Jin SHIN
;
Joo Seop CHUNG
;
Goon Jae CHO
;
Eun Yup LEE
Author Information
1. Department of Internal Medicine, School of Medicine, Pusan National University, Busan, Korea. hemon@pusan.ac.kr
- Publication Type:Case Report
- Keywords:
Henoch-Schonlein purpura;
Diffuse large B cell lymphoma;
Malignancy;
Vasculitis
- MeSH:
Abdominal Pain;
Aged;
Arterioles;
Biopsy;
Buttocks;
Colonoscopy;
Dermis;
Doxorubicin;
Drug Therapy;
Drug Therapy, Combination;
Etoposide;
Female;
Granulocytes;
Hematuria;
Humans;
Ifosfamide;
Immunoglobulin A;
Leg;
Lymph Nodes;
Lymphoma;
Lymphoma, B-Cell*;
Prednisolone;
Proteinuria;
Purpura;
Purpura, Schoenlein-Henoch*;
Recurrence;
Skin;
Tomography, X-Ray Computed;
Vasculitis;
Vincristine
- From:Korean Journal of Hematology
2007;42(2):162-166
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 69-year-old female was referred to our institution due to abdominal pain and palpable purpura on both buttocks and legs. A skin biopsy of her purpura revealed granulocyte infiltration and leucocytoclasia around the arterioles and venuoles at the dermis, as well as an elevated serum immunoglobulin A level, hematuria and proteinuria. Therefore she was diagnosed with Henoch-Schonlein purpura. She had been diagnosed with diffuse large B cell lymphoma after a biopsy of her left inguinal lymph node 12 years ago and received 6 cycles of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy, which was followed by a complete remission. Abdominal and chest CT revealed multiple lymph node enlargement and bowel wall thickening at the ileocecal area, and lesions were observed in a whole body PET CT scan. Recurrence of the diffuse large B cell lymphoma was confirmed by a biopsy of the ileocecal area via colonoscopy. The purpura was improved after oral prednisolone therapy and etoposide, oxaliplatin and ifosfamide salvage combination chemotherapy was used to treat the lymphoma.
