A Case of Unspecified Mature T-cell Leukemia with Clover-shaped, Multi-lobated Nuclei.
10.5045/kjh.2007.42.2.172
- Author:
Seung Tae LEE
1
;
Su Yon PARK
;
Hee Jin KIM
;
Sun Hee KIM
Author Information
1. Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. sunnyhk@smc.samsung.co.kr
- Publication Type:Case Report
- Keywords:
Mature T-cell leukemia;
WHO classification;
Multi-lobated
- MeSH:
Adult;
Bone Marrow;
Classification;
Eosinophilia;
Female;
Glycogen Storage Disease Type VI;
Human T-lymphotropic virus 1;
Humans;
Leukemia, Lymphoid;
Leukemia, Prolymphocytic, T-Cell;
Leukemia, T-Cell*;
Lymph Nodes;
Lymphocyte Count;
Middle Aged;
Sezary Syndrome;
T-Lymphocytes*;
World Health Organization
- From:Korean Journal of Hematology
2007;42(2):172-175
- CountryRepublic of Korea
- Language:English
-
Abstract:
Mature T-cell leukemias are a group of neoplasms derived from mature or post-thymic T-cells, and a number of distinctive disease entities have been defined in the World Health Organization (WHO) classification. Here we report a 54-year-old female patient with multi-lobated atypical cells expressing the classic T-cell antigens involving multiple lymph nodes, peripheral blood, and bone marrow. The clinical, laboratory, and pathologic features of her disease did not fit into any of the entities in the WHO Classification. There was no evidence of rapidly rising lymphocyte counts, TCL1 expression, eosinophilia, erythroderma, Sezary cells, autoimmune phenomena, cytotoxic granules, nor evidence of HTLV-1 infection, and thus, T-cell prolymphocytic leukemia, Sezary syndrome, T-cell granular lymphocytic leukemia, and adult T-cell leukemia/lymphoma were all ruled out. This case suggests that further characterization and definition of the "unclassifiable" cases of mature T-cell neoplasm is needed to better understand the group of disorders.
