FLT3 Internal Tandem Duplication in Acute Myeloid Leukemia with Normal Karyotype.
10.5045/kjh.2007.42.3.250
- Author:
Sang Ho KIM
1
;
Yeo Kyeoung KIM
;
Il Kwon LEE
;
Deog Yeon JO
;
Jong Ho WON
;
Jae Yong KWAK
;
Chang Yeol YIM
;
Moo Rim PARK
;
Deok Hwan YANG
;
Sang Hee CHO
;
Je Jung LEE
;
Ik Joo CHUNG
;
Hyeoung Joon KIM
Author Information
1. Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. hjoonk@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
FLT3/ITD;
Acute myeloid leukemia;
Normal karyotype
- MeSH:
Bone Marrow;
Diagnosis;
Humans;
Induction Chemotherapy;
Karyotype*;
Leukemia, Myeloid, Acute*;
Leukocyte Count;
Multivariate Analysis;
Polymerase Chain Reaction;
Prognosis
- From:Korean Journal of Hematology
2007;42(3):250-257
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The presence of FLT3 internal tandem dupulication (FLT3/ITD) in patients with acute myeloid leukemia (AML) with normal karyotype was investigated in order to evaluate its clinical and prognostic significance. METHODS: The FLT3/ITD was studied by PCR assay in bone marrow samples obtained from 123 patients at diagnosis. Ninety patients who received intensive induction chemotherapy were evaluated. RESULTS: Of total 123 patients, forty-seven (38.2%) demonstrated the aberrant FLT3/ITD. Patients with FLT3/ITD had significantly higher leukocyte counts at presentation than did patients without FLT3/ITD (P=0.04). By multivariate analysis, the FLT3/ITD was an independent prognostic factor of leukemic-free survival (LFS) (P=0.01) in AML patients with normal karyotype. CONCLUSION: This study demonstrated that the presence of the FLT3/ITD was a significant factor for poor prognosis in AML patients with normal karyotype.
