Therapeutic Efficacy of a Single Dose of Anti-D Immunoglobulin 50 microgram/kg in Childhood Acute Immune Thrombocytopenic Purpura.
10.5045/kjh.2007.42.3.258
- Author:
Ki Lyong NAM
1
;
Sang Hee CHO
;
Sung Wan YANG
;
Dong Woo SON
;
In Sang JEON
Author Information
1. Department of Pediatrics, Gil Medical Center, School of Medicine, Gachon University of Medicine and Science, Incheon, Korea. isjeon@gilhospital.com
- Publication Type:Original Article
- Keywords:
Immune thrombocytopenic purpura (ITP);
Anti-D;
Hemolytic anemia
- MeSH:
Anemia, Hemolytic;
Child;
Humans;
Immunoglobulins*;
Platelet Count;
Purpura, Thrombocytopenic, Idiopathic*
- From:Korean Journal of Hematology
2007;42(3):258-263
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: To investigate the efficacy and adverse effects of a single dose of anti-D immunoglobulin (50 microgram/kg) in Korean children with acute immune thrombocytopenic purpura (ITP). METHODS: We serially evaluated the platelet count in 21 acute ITP patients that were treated with anti-D immunoglobulin (50 microgram/kg) to determine how many patients achieved platelet counts over the levels of 20 x 10(3)/mm3, 50 x 10(3)/mm3 and 100 x 10(3)/mm3 after the infusion of anti-D immunoglobulin. In addition, constitutional symptoms were monitored and changes in the hemoglobin levels were serially evaluated. RESULTS: By three days after treatment, 90.5% of the patients had achieved a platelet count over 20 x 10(3)/mm3. At seven days after treatment, 66.7% of patients achieved a platelet count of 50 x 10(3)/mm3. In addition, at seven days after treatment 61.9% of patients achieved a platelet count of 100 x 10(3)/mm3. Constitutional adverse symptoms were observed 61.9% of patients, and the symptoms diminished spontaneously without any severe sequelaes. The decline of hemoglobin concentration after treatment recovered to the initial level after two weeks. CONCLUSION: A single dose of anti-D immunoglobulin (50 microgram/kg)was effective in Korean children with acute ITP to raise the platelet count rapidly. The adverse effects of anti-D immunoglobulin, including hemolytic anemia, were not severe to prevent the use of the anti-D.
