Evaluation of Peripheral White Blood Cell Count or Monocyte Count to Guide Timing of Mobilized Stem Cell Collection in Patients with Breast Cancer.
- Author:
Young Joo MIN
1
;
Cheolwon SUH
;
Hyo Jung KIM
;
Shin KIM
;
Eun Kyoung KIM
;
Geundoo JANG
;
Jinny PARK
;
Keon Uk PARK
;
Keehyun LEE
;
Tae Won KIM
;
Sung Bae KIM
;
Sang We KIM
;
Jung Shin LEE
;
Jae Hoo PARK
;
Woo Kun KIM
;
Sang Hee KIM
Author Information
1. Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan.
- Publication Type:Original Article
- Keywords:
Peripheral blood stem cells;
Apheresis;
White cell count;
Monocyte count;
Breast cancer
- MeSH:
Blood Component Removal;
Body Weight;
Breast Neoplasms*;
Breast*;
Humans;
Leukocyte Count*;
Leukocytes*;
Monocytes;
Retrospective Studies;
Stem Cells*
- From:Korean Journal of Hematology
2000;35(3-4):258-262
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The optimal timing of peripheral blood stem cell (PBSC) collection is essential to successful procurement of sufficient PBSC for engraftment. The purpose of this study was to evaluate the peripheral blood parameters that may predict the apheretic yield of circulating stem cells in patients with breast cancer. METHODS: We did a retrospective review of 29 patients with breast cancer (14 : high risk, 15 : metastatic disease) who underwent mobilizing therapy from Dec. 1992 to Jan. 1999. Immediately prior to 119 consecutive PBSC collection procedures, the PB white blood cell (WBC) and monocyte were determined and correlated with stem cell parameters namely, CD34+ cell and mononuclear cell content. RESULTS: The median of 0.57x106CD34+cells/kg patient body weight (range, 0-9.39) were collected per harvest. The WBC on the day of apheresis showed only weak correlation with the mononuclear cells collected (r=0.26). In contrast, the WBC count and monocyte count in PB did not correlated with CD34+ cells harvested CONCLUSION: WBC and monocyte count are not appropriate parameters to identify the exact timing for apheresis and predict the amount of peripheral blood stem cells collected in patients with breast cancer.
