A Case of Limbic Encephalitis Developed after Allogeneic Stem Cell Transplantation.
10.5045/kjh.2006.41.4.297
- Author:
Nam Sook PARK
1
;
Sang Eun PARK
;
Jae Min CHUN
;
Nam Hwan PARK
;
Yung Jun YANG
;
Kak Won YUN
;
Eun Hee SON
;
Hwan Jung YUN
;
Deog Yeon JO
;
Chang Jun SONG
;
Samyong KIM
Author Information
1. Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Korea. deogyeon@cnu.ac.kr
- Publication Type:Case Report
- Keywords:
Limbic encephalitis;
Allogeneic stem cell transplantation;
HHV-6
- MeSH:
Adolescent;
Amnesia, Retrograde;
Bone Marrow;
Bone Marrow Transplantation;
Brain;
Cerebrospinal Fluid;
Diagnosis;
Encephalitis;
Encephalitis, Viral;
Fever;
Ganciclovir;
Herpesvirus 1, Human;
Herpesvirus 6, Human;
Hippocampus;
Humans;
Limbic Encephalitis*;
Magnetic Resonance Imaging;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Stem Cell Transplantation*;
Stem Cells*;
Unrelated Donors
- From:Korean Journal of Hematology
2006;41(4):297-301
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Limbic encephalitis is a rare neurological syndrome, which develops after stem cell transplantation, and is characterized by a series of neurological symptoms, including retrograde amnesia, behavioral disturbance, and progressive intellectual deterioration and high signal intensity in the hippocampus on magnetic resonance imaging (MRI). Herein is described the case of a patient with limbic encephalitis, which developed after allogeneic bone marrow transplantation, and was possibly due to HHV-6 infection. An 18-year-old man, with acute lymphoid leukemia, who underwent HLA-matched unrelated donor bone marrow transplantation, developed a fever and chill accompanied by neurological symptoms, including behavioral disturbance and retrograde amnesia, during the bone marrow recovery phase. A brain MRI revealed bright signal-intensity in both hippocampi. Examination of his cerebrospinal fluid suggested viral encephalitis. Based on these findings, a diagnosis of viral limbic encephalitis was highly suspected. Tests for casual causes of viral limbic encephalitis, including the CMV, HZV and HSV-1 and 2, in serum or CSF were all negative. The encephalitis responded well to ganciclovir therapy.
