A Case of Chronic Active Epstein-Barr Virus Infection with Autoimmnune Hepatitis and a Coronary Aneurysm.
10.5045/kjh.2006.41.4.311
- Author:
Mi Jin KIM
1
;
Ji Joung LEE
;
Kyoung Soo PARK
;
Sun Young KIM
;
Hong Ryang KIL
Author Information
1. Department of Pediatrics, College of Medicine, Chungnam National University, Daejeon, Korea. sunyoung@cnuh.co.kr
- Publication Type:Case Report
- Keywords:
Chronic active EBV infection;
Autoimmune hepatitis;
Coronary aneurysm
- MeSH:
Anorexia;
Autoimmune Diseases;
B-Lymphocytes;
Child, Preschool;
Coronary Aneurysm*;
Epstein-Barr Virus Infections;
Erythrocytes;
Fever;
Hepatitis*;
Hepatitis, Autoimmune;
Herpesvirus 4, Human*;
Humans;
Infectious Mononucleosis;
Liver;
Liver Diseases;
Lymphatic Diseases;
Male;
Pharyngitis;
Prognosis
- From:Korean Journal of Hematology
2006;41(4):311-316
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Infectious mononucleosis caused by primary infection of Epstein-Barr virus (EBV) is a self-limiting lymphoproliferative disease, and shows concomitant clinical features such as pyrexia, anorexia, sore throat, cervical lymphadenopathy, liver dysfunction and hepatosplenomegaly. In rare cases, EBV establishes a latent infection in B lymphocytes and runs a chronic course and shows infectious mononucleosis-like symptoms repeatedly. This syndrome, named chronic active EBV infection, may trigger an autoimmune disease that mainly affectes the liver and red blood cells, and carries a very poor prognosis. The cardiovascular complications of chronic active EBV infection are very rare and may be associated with coronary arterial disease. This case describes a 5-year-old boy, who developed chronic active EBV infection and was diagnosed as having autoimmune hepatitis with a coronary aneurysm.
