A Case of Invasive Pulmonary Aspergillosis Cured with Liposomal Amphotericin, Granulocyte Transfusion and Surgery in an Allogeneic Hemopoietic Stem Cell Transplantation Recipient.
- Author:
Jae Wan PARK
1
;
Ihn Sub AHN
;
So Young CHONG
;
Myung Seo KANG
;
Yong Hee LEE
;
Doyeun OH
Author Information
1. Department of Internal Medicine, College of Medicine, Pochon CHA University, Pochon, Korea.
- Publication Type:Case Report
- Keywords:
Invasive aspergillosis;
Granulocyte transfusion;
Liposomal amphotericin;
Leukemia;
Allogeneic hemopoietic stem cell transplantation
- MeSH:
Adult;
Amphotericin B*;
Aspergillosis;
Bone Marrow;
Bone Marrow Transplantation;
Granulocyte Colony-Stimulating Factor;
Granulocytes*;
Humans;
Invasive Pulmonary Aspergillosis*;
Leukemia;
Mortality;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Prognosis;
Stem Cell Transplantation*;
Stem Cells*
- From:Korean Journal of Hematology
1999;34(4):625-629
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The prognosis of invasive aspergillosis in allogeneic bone marrow transplantation recipients is grave in the absence of bone marrow recovery in spite of antifungal treatment with amphotericin B. Beneficial role of granulocyte transfusion in neutropenic patients with fungal infection has been re-evaluated since granulocyte colony-stimulating factor made effective collection of granulocyte possible. And Liposomal amphotericin appears to be an effective alternative to conventional amphotericin B with much less toxicity. A 34-year-old patient with acute lymphoblastic leukemia developed invasive pulmonary aspergillosis during very early period of allogeneic hemopoietic stem cell transplantation. We treated the case successfully with liposomal amphotericin and granulocyte transfusion and surgery in spite of known high mortality of invasive aspergillosis in transplantation patients.
