A Case of Pleural Involvement in Patient with Waldenstr m's Macroglobulinemia.
- Author:
Joon Ho JANG
1
;
Jee Sook HAHN
;
Seung Hyuk HAN
;
Won Ki KO
;
Seung Tae LEE
;
Yoo Hong MIN
;
Yun Woong KO
;
Sung Kyu KIM
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Waldenstr m's macroglobulinemia;
Pleural involvement
- MeSH:
Aged;
Bone Marrow;
Dizziness;
Drug Therapy, Combination;
Dyspnea;
Electrophoresis;
Epistaxis;
Filtration;
gamma-Globulins;
Headache;
Humans;
Immunoelectrophoresis;
Immunoglobulin M;
Korea;
Lymphocytes;
Lymphoproliferative Disorders;
Male;
Plasma;
Pleural Effusion;
Thorax;
Waldenstrom Macroglobulinemia*
- From:Korean Journal of Hematology
1999;34(4):630-635
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Waldenstr m's macroglobulinemia (WM) is a rare lymphoproliferative disorder characterized by lymphocytic tumor infiltration of the bone marrow and monoclonal IgM gammopathy. There had been anecdotal reports of pleural involvement in WM. We experienced a case of WM with pleural involvement and reported here for the first time in Korea with review of literature. A 73-year-old male patient was admitted to our hospital due to dizziness and general weakness. Serum protein electrophoresis showed M-peak in the gamma-globulin region, which was revealed as IgM kappa macroglobulin by serum and urine immunoelectrophoresis. He complained headache, visual disturbance and epistaxis associated with hyperviscosity syndrome and plasma filtration and combination chemotherapy was performed immediately. Symptoms and laboratory parameters such as serum IgM level and globulin fraction were markedly improved thereafter. But during the treatment, insidiously progressive exertional dyspnea was developed and the chest X-ray showed bilateral pleural effusion. The pleural fluid contained abundant plasmacytoid lymphocytes with reactive mesothelial cells. His dyspnea was completely resolved with clearing of the radiographic pleural effusion after continued steroid therapy.
