A Case with Disseminated Macrophage-related Histiocytic Sarcoma Diagnosed by Positive Histiocytic Markers.
- Author:
Kee Won KIM
1
;
Suk Young PARK
;
Hee Jung KIM
;
Byung Hyun YOO
;
Sang Bum KANG
;
Jae Pil LEE
;
Eun Hee LEE
;
Kyung Shick LEE
Author Information
1. Division of Hematology-oncology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Malignant Histiocytosis;
Histiocytic Sarcoma
- MeSH:
Anemia, Refractory;
B-Lymphocytes;
Cell Lineage;
Classification;
Dendritic Cells;
Diagnosis;
Histiocytes;
Histiocytic Disorders, Malignant;
Histiocytic Sarcoma*;
Humans;
Jaundice;
Leukopenia;
Lymphatic Diseases;
Lymphocytes;
Lymphoma;
Macrophage Colony-Stimulating Factor;
Macrophages;
Muramidase;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
S100 Proteins;
T-Lymphocytes
- From:Korean Journal of Hematology
1999;34(4):641-645
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Malignant histiocytosis (MH) is characterized by an invasive, progressive proliferation of neoplastic histiocytes associated with jaundice, lymphadenopathy, refractory anemia, leukopenia, and often hepatic and splenic enlargement. As lymphoblastic leukemia and lymphoma are regarded as neoplasms of lymphoid cells, MH is thought to represent a malignant transformation of the macrophage and dendritic cells. A classification of malignant histiocytic disorders was oriented by cell lineage in the Histiocyte Society's 1987 version. So dendritic cell-related histiocytic sarcoma (localized or disseminated) and macrophage-related histiocytic sarcoma (localized or disseminated) are the recommended nosology. To establish the correct diagnosis, the major challenge seems to distinguish lymphoid from histiocytic cells. M-CSF receptor, lysozyme, Ki-M8, and S-100 protein, etc are useful markers for histiocytes and T-cell and B-cell lineage markers, such as CD3, CD20, and CD79, etc, for lymphocytes. We have experienced a patient with disseminated histiocytic sarcoma diagnosed by positive istiocytic markers, such as lysozyme, S-100 protein, and CD68.
