The immunobiology of cord blood transplantation.
10.5045/kjh.2010.45.4.224
- Author:
Paul SZABOLCS
1
Author Information
1. Department of Pediatrics, Pediatric Blood and Marrow Transplant Program and Department of Immunology, Duke University, Durham, USA. szabo001@mc.duke.edu
- Publication Type:Review
- Keywords:
Cord blood stem cell transplantation;
Opportunistic infection;
Immune reconstitution;
Adoptive immunotherapy;
Graft vs leukemia effect
- MeSH:
Biology;
Cord Blood Stem Cell Transplantation;
Fetal Blood;
Graft vs Leukemia Effect;
Immunotherapy, Adoptive;
Incidence;
Opportunistic Infections;
Recurrence;
Transplants
- From:Korean Journal of Hematology
2010;45(4):224-235
- CountryRepublic of Korea
- Language:English
-
Abstract:
Despite significant recent advances in the applicability and outcome following unrelated cord blood transplantation (UCBT), infections remain a major cause of mortality associated with poor immune recovery in the first 6 months after UCBT. Enhanced immune reconstitution not only could improve survival by reduced transplant related mortality, but may also favorably impact on relapse incidence by improved graft-versus-leukemia effects. This review will summarize our current understanding of the biology of immune recovery post-UCBT with an emphasis on adaptive T cell dependent immunity. New efforts to boost immunity will be also highlighted including our own laboratory, where ex vivo T cell expansion is pursued towards adoptive immunotherapy.
