A Case of Invasive Aspergillosis Involving Lung and Brain in Patient with Acute Leukemia.
- Author:
Dong Woo HYUN
1
;
Dong Hwan KIM
;
Jin Tae JUNG
;
Sang Kyun SOHN
;
Jae Tae LEE
;
Kyu Bo LEE
Author Information
1. Department of Internal Medicine, Kyungpook National University, School of Medicine, Taegu, Korea.
- Publication Type:Case Report
- Keywords:
Invasive Aspergillosis;
Lung, Brain;
Acute Leukemia
- MeSH:
Aspergillosis*;
Aspergillus;
Biopsy;
Bone Marrow Transplantation;
Brain*;
Causality;
Communicable Diseases;
Drug Therapy;
Early Diagnosis;
Fungi;
Humans;
Immunocompromised Host;
Leukemia*;
Lung*;
Magnetic Resonance Imaging;
Mortality;
Neutropenia;
Nose;
Skin;
Sputum
- From:Korean Journal of Hematology
1998;33(2):273-278
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Invasive aspergillosis is a life-threatening infectious disease in immunocompromised patients. Aspergillus is an ubiquitous mold present as normal flora in paranasal sinus, nose, skin and lung. The most important determinant of infection is the immune status of the patient, not the intensity of exposure. In acute leukemia and bone marrow transplantation, prolonged neutropenia is probably the most important predisposing factor. We experienced a case of invasive aspergillosis involving lung and brain in patient with acute leukemia during remission-induction chemotherapy. Invasive aspergillosis involving lung and brain was diagnosed by sputum culture, computed tomography (CT) guided lung biopsy and brain magnetic resonance imaging (MRI). Early diagnosis and prompt treatment for invasive aspergillosis are essential for lowering mortality in immunocompromised patients.
