A Case of B-Prolymphocytic Leukemia.
- Author:
Choong Hyoun RHEE
1
;
Yun Hee KANG
;
Chan Jeoung PARK
;
Hyun Sook CHI
;
Dae Young ZANG
Author Information
1. Department of Clinical Pathology, College of Medicine, Ulsan University, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
B-prolymphocytic leukemia;
Monoclonal gammopathy
- MeSH:
Aged;
Bone Marrow;
Diagnosis;
Humans;
Immunoglobulins;
Immunophenotyping;
Leukemia*;
Leukemia, Prolymphocytic;
Leukocytosis;
Lymphatic Diseases;
Lymphoproliferative Disorders;
Male;
Paraproteinemias;
Prevalence;
Splenomegaly
- From:Korean Journal of Hematology
1997;32(1):123-128
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Prolymphocytic leukemia (PLL) is a member of chronic lymphoproliferative disorders with relatively distinct clinical, morphologic, immunologic and prognostic features. The diagnosis of PLL is determined by more than 55% of prolymphocytes in the peripheral blood. It is characterized by leukocytosis, massive splenomegaly with little or no lymphadenopathy, and male prevalence. In immunophenotyping, the majority (80%) of the cases express B cell markers and the rest (20%), T cell type. We experienced a case of B-PLL. The patient was a 65 year-old man who presented with marked leukocytosis (110.5x109/L) and 78% of characteristic prolymphocytes in the peripheral blood. The bone marrow aspirate showed 13.6% of prolymphocytes and coarse granular positivity of prolymphocytes in PAS stain. The immunophenotyping of the leukemic prolymphocytes revealed the positivity of surface immunoglobulin (IgM, lambda type), HLA- DR and CD19. The monoclonal gammopathy (IgM, lambda type) was also detectable in the patient's serum.
