A Case of Bone Marrow Involvement of Hepatosplenic gamma delta-Cell Lymphoma.
- Author:
Seong Kyu LEE
1
;
Hee Yeon WOO
;
Quehn PARK
;
Sun Hee KIM
;
Hong Gee LEE
;
Young Hyeh KO
Author Information
1. Department of Clinical Pathology, Sungkyunkwan University School of Medicine, Seoul, Korea. sunnyhk@smc.samsung.co.kr
- Publication Type:Case Report
- Keywords:
Hepatosplenic;
gamma delta-cell;
Peripheral T-cell lymphoma;
Isochromosome 7q;
T-cell receptor
- MeSH:
Abdomen;
Anemia;
Biopsy;
Bone Marrow*;
Cytogenetics;
Diagnosis;
DNA Nucleotidylexotransferase;
Female;
Fever;
Gene Rearrangement;
Humans;
Isochromosomes;
Liver;
Lymphoma*;
Lymphoma, T-Cell, Peripheral;
Pelvis;
Receptors, Antigen, T-Cell;
Spleen;
Thrombocytopenia
- From:Korean Journal of Hematology
2002;37(2):134-137
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hepatosplenic gamma delta-cell lymphoma is a rare histologic type of peripheral T-cell lymphomas, clinically characterized by predominant involvement of liver and spleen, no or little adenopathy, and an often aggressive course. We report a case of bone marrow involvement of hepatosplenicgamma delta-cell lymphoma in a 21- year-old woman who presented with fever, anemia, thrombocytopenia, and hepatosplenomegaly. A lymphoma was found subsequently by bone marrow biopsy and computed tomography scan of the abdomen and pelvis. Immunologic characterization of lymphoma cells in bone marrow revealed positivity for CD2, CD3, and CD16/56, and negativity for CD4, CD5, CD7, CD8, CD34, and terminal deoxynucleotidyl transferase (TdT). Conventional cytogenetic studies revealed the presence of isochromosome 7q. Using the PCR-SSCP technique, monoclonal gene rearrangement of the T-cell receptor gamma chain was demonstrated. Thus, we could make a confirmatory diagnosis as hepatosplenic gamma delta-cell lymphoma.
