All-trans Retinoic Acid-induced Nephrotic-range Proteinuria in a Patient with Acute Promyelocytic Leukemia.
10.5045/kjh.2008.43.3.166
- Author:
Seong Uk LIM
1
;
Se Ryeon LEE
;
Seong Rye SEO
;
Jae Sook AHN
;
Yeo Kyeoung KIM
;
Deok Hwan YANG
;
Je Jung LEE
;
Hyeoung Joon KIM
Author Information
1. Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. drydh1685@hotmail.com
- Publication Type:Case Report
- Keywords:
Proteinuria;
Acute promyelocytic leukemia;
All-trans retinoic acid
- MeSH:
Dexamethasone;
Humans;
Leukemia, Promyelocytic, Acute;
Proteinuria;
Tretinoin
- From:Korean Journal of Hematology
2008;43(3):166-169
- CountryRepublic of Korea
- Language:English
-
Abstract:
All-trans retinoic acid (ATRA) is a potent differentiating agent for the treatment of acute promyelocytic leukemia (APL). Although ATRA is generally well-tolerated, some patients develop side effects, the most severe of which is ATRA syndrome. We report on a patient with APL who developed isolated nephrotic-range proteinuria during ATRA therapy for remission-induction. ATRA was discontinued and the proteinuria decreased significantly 5 days after dexamethasone treatment. The occurrence of isolated proteinuria during ATRA treatment is a rare adverse event.
