A Case of Epstein-Barr Virus-positive Diffuse, Large B-cell Lymphoma after Angioimmunoblastic T-cell Lymphoma.
10.5045/kjh.2008.43.3.174
- Author:
Yoon Hee CHOI
1
;
Hyo Seog KIM
;
Seung Bum NAM
;
Hye Jin KANG
;
Im Il NA
;
Sung Hyun YANG
;
Baek Yeol RYOO
Author Information
1. Department of Internal Medicine, Korea Cancer Center Hospital, Seoul, Korea. ryooby@kcch.re.kr
- Publication Type:Case Report
- Keywords:
Angioimmunoblastic T-cell lymphoma;
Diffuse large B-cell lymphoma;
Epstein-Barr virus
- MeSH:
B-Lymphocytes;
Herpesvirus 4, Human;
Humans;
Lymphoma, B-Cell;
Lymphoma, T-Cell;
Lymphoproliferative Disorders;
T-Lymphocytes
- From:Korean Journal of Hematology
2008;43(3):174-178
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Angioimmunoblastic T-cell lymphoma (AITL) is a systemic lymphoproliferative disorder that presents with profound immune dysfunction and immunodeficiency. As in many other immunodeficiencies, Epstein-Barr virus (EBV) associated B-cell lymphoid proliferation can occur in AITL but few cases of EBV-positive B-cell lymphoma have been reported in patients with preexisting AITL. We report a case of AITL in which EBV-positive diffuse large B-cell lymphoma (DLBCL) developed 13 months after the initial diagnosis of AITL. Although the exact mechanisms remain unclear, Epstein-Barr virus may have played a role in the pathogenesis of the secondary DLBCL
