Metachronous Mantle Cell Lymphoma with Leukemic Presentation in a Patient with Early Gastric Cancer: A Case Report.
10.5045/kjh.2008.43.4.247
- Author:
Wan Kyu EO
1
;
Kyu Jeung AHN
;
Woo In LEE
;
Sung Jig LIM
;
Jong Soo JEONG
Author Information
1. Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea. wkeo@dreamwiz.com
- Publication Type:Case Report
- Keywords:
Gastric cancer;
Metachronous second primary neoplasms;
Mantle cell lymphoma;
Leukemia
- MeSH:
Cytogenetics;
Gastrectomy;
Humans;
Korea;
Leukemia;
Lymphoma;
Lymphoma, Mantle-Cell;
Lymphoma, Non-Hodgkin;
Neoplasms, Second Primary;
Stomach Neoplasms
- From:Korean Journal of Hematology
2008;43(4):247-252
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report here on a case of metachronous second primary non-Hodgkin's lymphoma (NHL) that was diagnosed 6 years after performing subtotal gastrectomy for treating early gastric cancer (EGC). The subtype analysis revealed mantle cell lymphoma (MCL) of the blastic variant with a leukemic presentation, which was composed of mixed small and medium-sized cells. The immunohistochemical staining for cyclin-D1 was positive. The cytogenetic study revealed t(4;6). In Korea, the risk of developing a second primary cancer following gastric cancer was reported to be less than 3.4%, and NHL comprised less than 6.3% of this second primary cancer. Furthermore, MCL represents about 2% of all lymphomas in Korea. To the best of our knowledge, this is the first report of metachronous primary MCL with a leukemic presentation following curative resection of EGC.
