Effect of Donor Lymphocyte Infusion for a Patient with Isolated Knee Joint Relapse of Acute Lymphoblastic Leukemia after Allogeneic Bone Marrow Transplantation.
- Author:
Jusang KIM
1
;
Seok LEE
;
Yoo Jin KIM
;
Jihyang LIM
;
Myungshin KIM
;
Min Soo KIM
;
Seung Woo LEE
;
Yoon Hee PARK
;
Hee Je KIM
;
Dong Wook KIM
;
Jong Wook LEE
;
Woo Sung MIN
;
Chang Suk KANG
;
Chun Choo KIM
Author Information
1. Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. leeseok@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Isolated extramedullary relapse;
Knee joint;
Acute lymphoblastic leukemia;
Allogeneic bone marrow transplantation;
Donor lymphocyte infusion
- MeSH:
Adult;
Bone Marrow Transplantation*;
Bone Marrow*;
Drug Therapy;
Humans;
Knee Joint*;
Knee*;
Leukemia;
Lymphocytes*;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*;
Radiotherapy;
Recurrence*;
Tissue Donors*
- From:Korean Journal of Hematology
2003;38(2):131-135
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Isolated extramedullary relapse of acute lymphoblastic leukemia (ALL) after allogeneic bone marrow transplantation (BMT) in the absence of marrow involvement is a rare event, and the mechanisms underlying the selective involvement of extramedullary sites remain undefined. These might be due to relapse in sanctuary sites where the leukemic cells are resistant to preparative regimen, or a stronger graft-versus-leukemia effect in the marrow as compared with peripheral tissues. We report an adult ALL patient who experienced isolated extramedullary relapse in the right pretibial soft tissue and knee joint 42 months after allogeneic BMT. He was treated with localized radiotherapy followed by systemic chemotherapy and donor lymphocyte infusion. After treatment, he is currently well with no evidence of leukemia recurrence for 12 months.
